Drug interactions
riociguat + sildenafil
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Severe hypotension; contraindicated.
Mechanism of action
Dual sGC stimulation + PDE5 inhibition.
Clinical management
Contraindicated.
Drug reference
References
Frequently asked questions
Can I take riociguat with sildenafil?
The interaction is rated: Contraindicated. Severe hypotension; contraindicated.
How serious is the interaction between riociguat and sildenafil?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between riociguat and sildenafil managed?
Contraindicated.
Why do riociguat and sildenafil interact?
Dual sGC stimulation + PDE5 inhibition.
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