Diseases
glucocorticoid-induced osteoporosis
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Glucocorticoid-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis, the most common cause before 50 years of age, and the most common iatrogenic cause of the disease. Previous and current exposure to glucocorticoids (GCs) increases the risk of fracture and bone loss.
Symptoms
- back pain, caused by a fractured or collapsed vertebra
- loss of height over time
- a stooped posture
- a bone that breaks much more easily than expected
Causes
- glucocorticoids decrease the function of the remaining osteoblasts directly and indirectly through the inhibition of insulin-like growth factor i expression. the stimulation of bone resorption is likely responsible for
- low calcium intake
Risk factors
- gastrointestinal surgery.
- the older people get, the greater the risk of osteoporosis.
- women are much more likely to develop osteoporosis than men.
Diagnosis
- ultrasound
- bone density test
- ct scan
- lab test
Medicines used
Frequently asked questions
What is glucocorticoid-induced osteoporosis?
Glucocorticoid-induced osteoporosis (GIOP) is the most common cause of secondary osteoporosis, the most common cause before 50 years of age, and the most common iatrogenic cause of the disease. Previous and current exposure to glucocorticoids (GCs) increases the risk of fracture and bone loss.
What are the symptoms of glucocorticoid-induced osteoporosis?
back pain, caused by a fractured or collapsed vertebra, loss of height over time, a stooped posture, a bone that breaks much more easily than expected
What causes glucocorticoid-induced osteoporosis?
glucocorticoids decrease the function of the remaining osteoblasts directly and indirectly through the inhibition of insulin-like growth factor i expression. the stimulation of bone resorption is likely responsible for; low calcium intake
Which medicines are used for glucocorticoid-induced osteoporosis?
risedronate, zoledronic acid
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