Drug reference
dapagliflozin-saxagliptin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Gastrointestinal Tract (Combination(GIT))
Mechanism of action
Dapagliflozin: Selective sodium-glucose transporter-2 (SGLT2) inhibitor; SGLT-2, expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen; SGLT2 inhibitors reduce glucose reabsorption and lower the renal threshold for glucose, thereby increasing urinary glucose excretion
Saxagliptin: Dipeptidyl peptidase IV (DPP-4) inhibition that results in increased incretin hormones and enhanced glycemic control; incretin hormones cause insulin release from the pancreatic beta cells in a glucose-dependent manner, but are inactivated by the DDP-4 enzyme within minutes
Common side effects
- Urinary tract infections
- Headaches
- Back Pain
- Dyslipidemia
- Diarrhea
- Upper respiratory tract infection (URI)
Contraindications
- History of hypersensitivity to dapagliflozin or saxagliptin, including anaphylaxis, angioedema, or exfoliative skin conditions
- Moderate-to-severe renal impairment (eGFR <45 mL/min/1.73 m²), end-stage renal disease, or patients on dialysis
Related conditions
Frequently asked questions
What drug class is dapagliflozin-saxagliptin?
dapagliflozin-saxagliptin belongs to: Gastrointestinal Tract.
How does dapagliflozin-saxagliptin work?
Dapagliflozin: Selective sodium-glucose transporter-2 (SGLT2) inhibitor; SGLT-2, expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen; SGLT2 inhibitors reduce glucose reabsorption and lower the renal threshold for glucose, thereby increasing urinary glucose excretion Saxagliptin: Dipeptidyl peptidase IV (DPP-4) inhibition that results in increased incretin hormones and enhanced glycemic control; incretin hormones cause insulin release from the pancreatic beta cells in a glucose-dependent manner, but are inactivated by the DDP-4 enzyme within minutes
What are the common side effects of dapagliflozin-saxagliptin?
Urinary tract infections, Headaches, Back Pain, Dyslipidemia, Diarrhea, Upper respiratory tract infection (URI)
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