Drug reference
diphenoxylate-atropine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Gastrointestinal Tract (Anti Motility)
Mechanism of action
Diphenoxylate: Acts on smooth muscle of intestinal tract, inhibiting GI motility and excessive GI propulsion (like morphine). Atropine: Subtherapeutic quantity of atropine is added to discourage deliberate overdose of diphenoxylate.
Common side effects
- Anticholinergic effects
- Sedation
- Blurred vision
- Dryness of skin or mouth
Contraindications
- Hypersensitivity to diphenoxylate or atropine Children aged <6 years owing to risks of respiratory and CNS depression (tablets only) Obstructive jaundice Diarrhea associated with pseudomembranous enterocolitis or infectious enterotoxin-producing bacteria
Related conditions
Frequently asked questions
What drug class is diphenoxylate-atropine?
diphenoxylate-atropine belongs to: Gastrointestinal Tract.
How does diphenoxylate-atropine work?
Diphenoxylate: Acts on smooth muscle of intestinal tract, inhibiting GI motility and excessive GI propulsion (like morphine). Atropine: Subtherapeutic quantity of atropine is added to discourage deliberate overdose of diphenoxylate.
What are the common side effects of diphenoxylate-atropine?
Anticholinergic effects, Sedation, Blurred vision, Dryness of skin or mouth
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