Drug reference
dosulepin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (Miscellaneous(CNS))
Mechanism of action
Dosulepin potentiates the effects of biogenic amines in the brain by inhibition of their reuptake at nerve terminals. Dosulepin is active in inhibiting the reuptake of noradrenaline, 5-hydroxytryptamine (5HT) and dopamine. Dosulepin also reduces and/or down regulates central noradrenaline receptor numbers and reduces noradrenaline-induced cyclic AMP formation in the brain.
Common side effects
- thrombocytopenia
- Weight gain, and blood sugar concentration changes.
- Confusion, hypomania, and nervousness.
- Raised intraocular pressure.
- increased appetite
Related conditions
Frequently asked questions
What drug class is dosulepin?
dosulepin belongs to: Central Nervous System.
How does dosulepin work?
Dosulepin potentiates the effects of biogenic amines in the brain by inhibition of their reuptake at nerve terminals. Dosulepin is active in inhibiting the reuptake of noradrenaline, 5-hydroxytryptamine (5HT) and dopamine. Dosulepin also reduces and/or down regulates central noradrenaline receptor numbers and reduces noradrenaline-induced cyclic AMP formation in the brain.
What are the common side effects of dosulepin?
thrombocytopenia, Weight gain, and blood sugar concentration changes., Confusion, hypomania, and nervousness., Raised intraocular pressure., increased appetite
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