Drug interactions
Cyclobenzaprine + Dosulepin
Severity: Major
Cyclobenzaprine and Dosulepin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants, and combining it with dosulepin adds sedative, anticholinergic and cardiac conduction effects. Serotonergic effects and arrhythmia risk may also be increased, particularly in overdose or in older patients.
What this interaction means in plain words
Cyclobenzaprine and Dosulepin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclobenzaprine belongs to Musculoskeletal; Dosulepin belongs to Central Nervous System.
Why it happens
Additive anticholinergic, sedative, serotonergic and conduction-slowing effects of two tricyclic-type compounds.
What to do
Avoid the combination where possible; if needed, use low doses and monitor for sedation, anticholinergic toxicity, serotonin toxicity and ECG changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Cyclobenzaprine with Dosulepin?
MediHelp rates the interaction as major. Cyclobenzaprine and Dosulepin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclobenzaprine is structurally related to tricyclic antidepressants, and combining it with dosulepin adds sedative, anticholinergic and cardiac conduction effects. Serotonergic effects and arrhythmia risk may also be increased, particularly in overdose or in older patients.
How serious is the interaction between Cyclobenzaprine and Dosulepin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, use low doses and monitor for sedation, anticholinergic toxicity, serotonin toxicity and ECG changes.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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