Drug reference
guselkumab
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Miscellaneous (Miscellaneous)
Mechanism of action
Monoclonal antibody (IgG1-lambda) that inhibits IL-23 by selectively binding to p19 subunit of IL-23; IL-23 is a natural cytokine associated with inflammatory and immune responses; guselkumab inhibits the proinflammatory actions of IL-23, thereby decreasing cytokine and chemokine release
Common side effects
- Infections
- Headaches
- Elevated liver function test values
- Injection site pain.
- Upper respiratory tract infections
Contraindications
- History of serious hypersensitivity reaction to guselkumab or to any of the excipients
Known interactions (1)
Related conditions
Frequently asked questions
What drug class is guselkumab?
guselkumab belongs to: Miscellaneous.
How does guselkumab work?
Monoclonal antibody (IgG1-lambda) that inhibits IL-23 by selectively binding to p19 subunit of IL-23; IL-23 is a natural cytokine associated with inflammatory and immune responses; guselkumab inhibits the proinflammatory actions of IL-23, thereby decreasing cytokine and chemokine release
What are the common side effects of guselkumab?
Infections, Headaches, Elevated liver function test values, Injection site pain., Upper respiratory tract infections
Which drugs interact with guselkumab?
upadacitinib
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