Drug interactions
Guselkumab + Influenza virus vaccine quadrivalent intranasal
Severity: Major
Guselkumab and Influenza virus vaccine quadrivalent intranasal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine is live attenuated. In patients on guselkumab, impaired immune control could allow vaccine-virus replication, and safety has not been established.
What this interaction means in plain words
Guselkumab and Influenza virus vaccine quadrivalent intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
IL-23 inhibition may impair immune control of replicating live vaccine virus; theoretical.
What to do
Use an inactivated injectable influenza vaccine instead of the intranasal product during guselkumab therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Guselkumab and Influenza virus vaccine quadrivalent intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Guselkumab
Frequently asked questions
Can I take Guselkumab with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as major. Guselkumab and Influenza virus vaccine quadrivalent intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The intranasal influenza vaccine is live attenuated. In patients on guselkumab, impaired immune control could allow vaccine-virus replication, and safety has not been established.
How serious is the interaction between Guselkumab and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an inactivated injectable influenza vaccine instead of the intranasal product during guselkumab therapy.
What other medicines interact with Guselkumab?
MediHelp also lists interactions of Guselkumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Measles mumps and rubella vaccine live. The full list is on the Guselkumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
