Drug reference
ibrutinib
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Oncology (Anti Neoplastics)
Mechanism of action
Bruton’s tyrosine kinase (BTK) inhibitor; forms a covalent bond with a cysteine residue in the BTK active site, leading to inhibition of BTK enzymatic activity; BTK is a signaling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways
BTK’s role in signaling through the B-cell surface receptors results in activation of pathways necessary for B-cell trafficking, chemotaxis, and adhesion
Common side effects
- Fatigue
- Nausea
- Hemorrhage
- Hemoglobin decreased
- Bruising
- Neutrophils decreased
- Increased serum creatinine, 1.5 x ULN
- Diarrhea
- Platelets decreased
- URI infection
Known interactions (2)
Related conditions
Frequently asked questions
What drug class is ibrutinib?
ibrutinib belongs to: Oncology.
How does ibrutinib work?
Bruton’s tyrosine kinase (BTK) inhibitor; forms a covalent bond with a cysteine residue in the BTK active site, leading to inhibition of BTK enzymatic activity; BTK is a signaling molecule of the B-cell antigen receptor (BCR) and cytokine receptor pathways BTK’s role in signaling through the B-cell surface receptors results in activation of pathways necessary for B-cell trafficking, chemotaxis, and adhesion
What are the common side effects of ibrutinib?
Fatigue, Nausea, Hemorrhage, Hemoglobin decreased, Bruising, Neutrophils decreased, Increased serum creatinine, 1.5 x ULN, Diarrhea, Platelets decreased, URI infection
Which drugs interact with ibrutinib?
measles mumps and rubella vaccine, chloramphenicol
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