Drug interactions
Cilostazol + Ibrutinib
Severity: Major
Cilostazol and Ibrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib inhibits platelet function and is associated with bleeding, including serious hemorrhage. Combining it with an antiplatelet agent such as cilostazol may further increase bleeding risk.
What this interaction means in plain words
Cilostazol and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cilostazol belongs to Cardiovascular; Ibrutinib belongs to Oncology.
Why it happens
Additive platelet inhibition through BTK inhibition by ibrutinib and PDE3 inhibition by cilostazol.
What to do
Avoid the combination if possible; if needed, monitor closely for bleeding and consider the timing of procedures, since ibrutinib may need to be held around surgery.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cilostazol
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Cilostazol with Ibrutinib?
MediHelp rates the interaction as major. Cilostazol and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibrutinib inhibits platelet function and is associated with bleeding, including serious hemorrhage. Combining it with an antiplatelet agent such as cilostazol may further increase bleeding risk.
How serious is the interaction between Cilostazol and Ibrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if needed, monitor closely for bleeding and consider the timing of procedures, since ibrutinib may need to be held around surgery.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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