Drug reference
noradrenaline
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Endocrine (Adrenocortical Drugs)
Mechanism of action
Strong beta1- and alpha-adrenergic effects and moderate beta2 effects, which increase cardiac output and heart rate, decrease renal perfusion and PVR, and cause variable BP effects
Common side effects
- Bradycardia
- Confusion
- Anxiety
- Hypertension
- Arrhythmia
- Dyspnea, with or without respiratory difficulty
Boxed warnings
- Antidote for extravasation ischemia: To prevent sloughing and necrosis in areas where extravasation has taken place, infiltrate areas promptly with 10-15 mL of saline solution containing 5-10 mg of phentolamine mesylate for injection Use syringe with fine hypodermic needle, with the solution being infiltrated liberally throughout the area, which is easily identified by its cold, hard, pallid appearance
Contraindications
- Patients who are hypotensive from blood volume deficits except as an emergency measure to maintain coronary and cerebral artery perfusion until blood volume replacement therapy can be completed
- Peripheral vascular thrombosis (except for lifesaving procedures)
- Concomitant use with some general anesthetics cyclopropane (not available in the US), halothane (not available in the US)
Related conditions
Frequently asked questions
What drug class is noradrenaline?
noradrenaline belongs to: Endocrine.
How does noradrenaline work?
Strong beta1- and alpha-adrenergic effects and moderate beta2 effects, which increase cardiac output and heart rate, decrease renal perfusion and PVR, and cause variable BP effects
What are the common side effects of noradrenaline?
Bradycardia, Confusion, Anxiety, Hypertension, Arrhythmia, Dyspnea, with or without respiratory difficulty
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