Drug reference
pegloticase
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Genitourinary (Miscellaneous(Genitourinary))
Mechanism of action
Recombinant, pegylated uric acid specific enzyme; achieves its therapeutic effect by catalyzing oxidation of uric acid to allantoin, thereby lowering serum uric acid levels
Common side effects
- Pruritus
- Urticaria
- Nausea
- Chest pain
- Erythema
- Chest discomfort
- Gout flares
- Infusion reactions
Boxed warnings
- Anaphylaxis and infusion reactions have been reported; these reactions may occur with any infusion, including the first, and typically manifest within 2 h of infusion (although delayed-type hypersensitivity has also been reported) Only administer in a healthcare setting, and monitor for appropriate period following infusion Premedicate with antihistamines and corticosteroids Risk for anaphylaxis is higher if serum uric acid level >6 mg/dL, monitor serum uric acid levels before infusion and consider discontinuing if levels increase to >6 mg/dL (particularly if 2 consecutive levels of…
Contraindications
- History of serious hypersensitivity, including anaphylaxis, to pegloticase or its components
- G6PD-deficiency (increased risk of hemolysis and methemoglobinemia)
Related conditions
Frequently asked questions
What drug class is pegloticase?
pegloticase belongs to: Genitourinary.
How does pegloticase work?
Recombinant, pegylated uric acid specific enzyme; achieves its therapeutic effect by catalyzing oxidation of uric acid to allantoin, thereby lowering serum uric acid levels
What are the common side effects of pegloticase?
Pruritus, Urticaria, Nausea, Chest pain, Erythema, Chest discomfort, Gout flares, Infusion reactions
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