Drug interactions
Certolizumab pegol + Pegloticase
Severity: Minor
Certolizumab pegol and Pegloticase: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegloticase can induce anti-PEG antibodies that might bind other pegylated drugs, such as certolizumab pegol, and speed their clearance. The clinical significance is unknown, and it is largely theoretical.
What this interaction means in plain words
Certolizumab pegol and Pegloticase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Certolizumab pegol belongs to Musculoskeletal; Pegloticase belongs to Genitourinary.
Why it happens
Possible anti-PEG antibody cross-reactivity increasing clearance of pegylated products; not well established.
What to do
Monitor for loss of certolizumab efficacy or infusion-type reactions. No empirical dose change is recommended.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Certolizumab pegol
- Adenovirus types 4 and 7 live + Certolizumab pegol Contraindicated
- Bcg intravesical live + Certolizumab pegol Contraindicated
- Bcg vaccine live + Certolizumab pegol Contraindicated
- Certolizumab pegol + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine Contraindicated
- Certolizumab pegol + Measles mumps and rubella vaccine live Contraindicated
Other interactions of Pegloticase
Frequently asked questions
Can I take Certolizumab pegol with Pegloticase?
MediHelp rates the interaction as minor. Certolizumab pegol and Pegloticase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pegloticase can induce anti-PEG antibodies that might bind other pegylated drugs, such as certolizumab pegol, and speed their clearance. The clinical significance is unknown, and it is largely theoretical.
How serious is the interaction between Certolizumab pegol and Pegloticase?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of certolizumab efficacy or infusion-type reactions. No empirical dose change is recommended.
What other medicines interact with Certolizumab pegol?
MediHelp also lists interactions of Certolizumab pegol with, for example, Adenovirus types 4 and 7 live, Bcg intravesical live, Bcg vaccine live. The full list is on the Certolizumab pegol page.
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