Drug reference
pramipexole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Cardiovascular (Miscellaneous(CVS))
Mechanism of action
Non-ergot dopamine D2 receptor agonist; strong affinity for D2 and D3 receptors; binding to these receptors increases dopamine activity on nerves of striatum and substantia nigra
Common side effects
- Insomnia
- Constipation
- Dizziness
- Somnolence
- Nausea
- Dyskinesia
- Postural hypotension
- Hallucination
Known interactions (6)
- amisulpride + pramipexole Contraindicated
- chlorpromazine + pramipexole Major
- fluphenazine + pramipexole Major
- haloperidol + pramipexole Major
- aripiprazole + pramipexole Moderate
- clozapine + pramipexole Moderate
Related conditions
Frequently asked questions
What drug class is pramipexole?
pramipexole belongs to: Cardiovascular.
How does pramipexole work?
Non-ergot dopamine D2 receptor agonist; strong affinity for D2 and D3 receptors; binding to these receptors increases dopamine activity on nerves of striatum and substantia nigra
What are the common side effects of pramipexole?
Insomnia, Constipation, Dizziness, Somnolence, Nausea, Dyskinesia, Postural hypotension, Hallucination
Which drugs interact with pramipexole?
amisulpride, chlorpromazine, fluphenazine, haloperidol, aripiprazole, clozapine
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.