Drug interactions
Iloperidone + Pramipexole
Severity: Major
Iloperidone and Pramipexole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an antipsychotic with D2 antagonism, which can counteract the dopaminergic benefit of pramipexole and worsen motor symptoms. Conversely, pramipexole may aggravate psychosis. The combination makes both conditions harder to control.
What this interaction means in plain words
Iloperidone and Pramipexole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Iloperidone belongs to Central Nervous System; Pramipexole belongs to Cardiovascular.
Why it happens
Opposing actions at dopamine D2 receptors.
What to do
Avoid if possible; in Parkinson disease with psychosis, use quetiapine, clozapine or pimavanserin instead. Monitor motor function and psychiatric symptoms if coadministration is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Loxapine inhaled + Pramipexole Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Iloperidone with Pramipexole?
MediHelp rates the interaction as major. Iloperidone and Pramipexole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iloperidone is an antipsychotic with D2 antagonism, which can counteract the dopaminergic benefit of pramipexole and worsen motor symptoms. Conversely, pramipexole may aggravate psychosis. The combination makes both conditions harder to control.
How serious is the interaction between Iloperidone and Pramipexole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; in Parkinson disease with psychosis, use quetiapine, clozapine or pimavanserin instead. Monitor motor function and psychiatric symptoms if coadministration is unavoidable.
What other medicines interact with Pramipexole?
MediHelp also lists interactions of Pramipexole with, for example, Amisulpride, Chlorpromazine, Droperidol. The full list is on the Pramipexole page.
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