Drug reference
prucalopride
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Gastrointestinal Tract (Miscellaneous(GIT))
Mechanism of action
Selective serotonin type 4 (5-HT4) receptor agonist; elicits GI prokinetic actions that stimulates colonic peristalsis (high-amplitude propagating contractions [HAPCs]), which increases bowel motility.
Common side effects
- Headache
- Nausea
- Abdominal pain
- Diarrhea
Contraindications
- Hypersensitivity Intestinal perforation or obstruction due to structural or functional disorder of gut wall, obstructive ileus, severe inflammatory conditions of the intestinal tract (eg, Crohn disease, ulcerative colitis, toxic megacolon/megarectum)
Known interactions (1)
- Mosapride + prucalopride Moderate
Related conditions
Frequently asked questions
What drug class is prucalopride?
prucalopride belongs to: Gastrointestinal Tract.
How does prucalopride work?
Selective serotonin type 4 (5-HT4) receptor agonist; elicits GI prokinetic actions that stimulates colonic peristalsis (high-amplitude propagating contractions [HAPCs]), which increases bowel motility.
What are the common side effects of prucalopride?
Headache, Nausea, Abdominal pain, Diarrhea
Which drugs interact with prucalopride?
Mosapride
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