Drug interactions
sirolimus + voriconazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Marked ↑ sirolimus → toxicity; avoid.
Mechanism of action
CYP3A4 inhibition.
Clinical management
Avoid co-use; consider alternative antifungal.
Drug reference
References
Frequently asked questions
Can I take sirolimus with voriconazole?
The interaction is rated: Major. Marked ↑ sirolimus → toxicity; avoid.
How serious is the interaction between sirolimus and voriconazole?
The interaction is rated: Major. Evidence level: High.
How is the interaction between sirolimus and voriconazole managed?
Avoid co-use; consider alternative antifungal.
Why do sirolimus and voriconazole interact?
CYP3A4 inhibition.
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