Drug reference
sitagliptin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Endocrine (Peptide analogues)
Mechanism of action
Dipeptyl peptidase-IV (DPP-4) inhibitor; increases and prolongs incretin hormone activity, which is inactivated by DPP-4 enzyme, Incretins increase insulin release and synthesis from pancreatic beta cells and reduce glucagon secretion from pancreatic alpha cells
Common side effects
- Upper respiratory tract infection
- Nasopharyngitis
- Constipation
- Headache
- Hypoglycemia
Known interactions (137)
- albiglutide + sitagliptin Moderate
- amlodipine-benazepril + sitagliptin Moderate
- aripiprazole + sitagliptin Moderate
- asenapine + sitagliptin Moderate
- benazepril + sitagliptin Moderate
- bisoprolol + sitagliptin Moderate
- captopril + sitagliptin Moderate
- captopril-hydrochlorothiazide + sitagliptin Moderate
- chlorpropamide + sitagliptin Moderate
- chlorthalidone + sitagliptin Moderate
- clozapine + sitagliptin Moderate
- darunavir + sitagliptin Moderate
- dexamethasone + sitagliptin Moderate
- dulaglutide + sitagliptin Moderate
- exenatide + sitagliptin Moderate
- exenatide injectable + sitagliptin Moderate
- fleroxacin + sitagliptin Moderate
- gliclazide + sitagliptin Moderate
- glimepiride + sitagliptin Moderate
- glimepiride-pioglitazone + sitagliptin Moderate
- glipizide + sitagliptin Moderate
- glipizide-metformin + sitagliptin Moderate
- glyburide + sitagliptin Moderate
- glyburide-metformin + sitagliptin Moderate
- hydrocortisone + sitagliptin Moderate
- iloperidone + sitagliptin Moderate
- indinavir + sitagliptin Moderate
- insulin aspart + sitagliptin Moderate
- insulin aspart protamine / insulin aspart + sitagliptin Moderate
- insulin aspart-insulin aspart protamine + sitagliptin Moderate
- insulin degludec + sitagliptin Moderate
- insulin degludec / insulin aspart + sitagliptin Moderate
- insulin degludec-insulin aspart + sitagliptin Moderate
- insulin degludec-liraglutide + sitagliptin Moderate
- insulin detemir + sitagliptin Moderate
- insulin glargine + sitagliptin Moderate
- insulin glargine-lixisenatide + sitagliptin Moderate
- insulin glulisine + sitagliptin Moderate
- insulin inhaled + sitagliptin Moderate
- insulin isophane human / insulin regular human + sitagliptin Moderate
- insulin isophane protamine human + sitagliptin Moderate
- insulin lispro + sitagliptin Moderate
- insulin lispro protamine / insulin lispro + sitagliptin Moderate
- insulin neutral human + sitagliptin Moderate
- insulin neutral human-insulin isophane protamine human + sitagliptin Moderate
- insulin nph + sitagliptin Moderate
- insulin regular human + sitagliptin Moderate
- liraglutide + sitagliptin Moderate
- lisinopril + sitagliptin Moderate
- lonapegsomatropin + sitagliptin Moderate
Related conditions
Frequently asked questions
What drug class is sitagliptin?
sitagliptin belongs to: Endocrine.
How does sitagliptin work?
Dipeptyl peptidase-IV (DPP-4) inhibitor; increases and prolongs incretin hormone activity, which is inactivated by DPP-4 enzyme, Incretins increase insulin release and synthesis from pancreatic beta cells and reduce glucagon secretion from pancreatic alpha cells
What are the common side effects of sitagliptin?
Upper respiratory tract infection, Nasopharyngitis, Constipation, Headache, Hypoglycemia
Which drugs interact with sitagliptin?
albiglutide, amlodipine-benazepril, aripiprazole, asenapine, benazepril, bisoprolol, captopril, captopril-hydrochlorothiazide, chlorpropamide, chlorthalidone, clozapine, darunavir, dexamethasone, dulaglutide, exenatide
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.