Drug interactions
Activated Charcoal + Amlodipine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Activated charcoal can adsorb orally administered amlodipine in the GI tract, reducing its absorption and antihypertensive effect when given around the same time.
Mechanism of action
Gastrointestinal adsorption of amlodipine onto activated charcoal leads to decreased bioavailability.
Clinical management
Avoid coadministration. If charcoal is required, separate administration from oral amlodipine by at least 2 hours (consider up to 4 hours given amlodipine’s slow absorption). Monitor blood pressure and clinical response; adjust dosing schedule if needed.
Drug reference
References
- Activated Charcoal: Drug Information — Lexicomp
- Amlodipine: Drug Information — Lexicomp
- Gastrointestinal decontamination of the poisoned patient — UpToDate
Frequently asked questions
Can I take Activated Charcoal with Amlodipine?
The interaction is rated: Moderate. Activated charcoal can adsorb orally administered amlodipine in the GI tract, reducing its absorption and antihypertensive effect when given around the same time.
How serious is the interaction between Activated Charcoal and Amlodipine?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between Activated Charcoal and Amlodipine managed?
Avoid coadministration. If charcoal is required, separate administration from oral amlodipine by at least 2 hours (consider up to 4 hours given amlodipine’s slow absorption). Monitor blood pressure and clinical response; adjust dosing schedule if needed.
Why do Activated Charcoal and Amlodipine interact?
Gastrointestinal adsorption of amlodipine onto activated charcoal leads to decreased bioavailability.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.