Drug interactions
Amlodipine + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Major
Amlodipine and Ombitasvir / paritaprevir / ritonavir and dasabuvir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir and paritaprevir inhibit CYP3A4 and substantially increase amlodipine exposure. This raises the risk of hypotension and peripheral edema.
What this interaction means in plain words
Amlodipine and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of CYP3A4 by ritonavir-boosted regimen reduces amlodipine clearance.
What to do
Reduce the amlodipine dose by at least half and monitor for hypotension and edema. Consider further reduction or an alternative antihypertensive if symptoms occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Amlodipine
- Amifostine + Amlodipine Major
- Activated Charcoal + Amlodipine Moderate
- Aldesleukin + Amlodipine Moderate
- Alfuzosin + Amlodipine Moderate
- Amlodipine + Apalutamide Moderate
- Amlodipine + Asenapine Moderate
Frequently asked questions
Can I take Amlodipine with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as major. Amlodipine and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir and paritaprevir inhibit CYP3A4 and substantially increase amlodipine exposure. This raises the risk of hypotension and peripheral edema.
How serious is the interaction between Amlodipine and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the amlodipine dose by at least half and monitor for hypotension and edema. Consider further reduction or an alternative antihypertensive if symptoms occur.
What other medicines interact with Amlodipine?
MediHelp also lists interactions of Amlodipine with, for example, Amifostine, Activated Charcoal, Aldesleukin. The full list is on the Amlodipine page.
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