Drug interactions
Alogliptin-metformin + Glibenclamide
Severity: Moderate
Alogliptin-metformin and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a DPP-4 inhibitor with a sulfonylurea raises the risk of hypoglycemia. Glyburide has a long-acting active metabolite, so hypoglycemia may be prolonged, especially in renal impairment or older patients.
What this interaction means in plain words
Alogliptin-metformin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alogliptin-metformin belongs to Endocrine; Glibenclamide belongs to Endocrine.
Why it happens
Additive insulin-secretory effects of alogliptin (glucose-dependent) and glyburide.
What to do
Consider reducing the glyburide dose when starting alogliptin-metformin, and monitor glucose closely. Be especially careful in elderly patients or those with reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Alogliptin-metformin
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Alogliptin-metformin with Glibenclamide?
MediHelp rates the interaction as moderate. Alogliptin-metformin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a DPP-4 inhibitor with a sulfonylurea raises the risk of hypoglycemia. Glyburide has a long-acting active metabolite, so hypoglycemia may be prolonged, especially in renal impairment or older patients.
How serious is the interaction between Alogliptin-metformin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when starting alogliptin-metformin, and monitor glucose closely. Be especially careful in elderly patients or those with reduced renal function.
What other medicines interact with Alogliptin-metformin?
MediHelp also lists interactions of Alogliptin-metformin with, for example, Clozapine, Contrast media, Diatrizoate. The full list is on the Alogliptin-metformin page.
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