Drug interactions
Alogliptin-metformin + Ibuprofen / famotidine
Severity: Minor
Alogliptin-metformin and Ibuprofen / famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine is a cation handled by renal tubular secretion and may modestly raise metformin exposure. Ibuprofen can reduce renal function in susceptible patients, which could reduce metformin clearance. In patients with normal renal function the effect is usually small.
What this interaction means in plain words
Alogliptin-metformin and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular cation transport and possible NSAID-related reduction in renal function.
What to do
Monitor renal function in patients with kidney impairment, dehydration or advanced age, and hold metformin if acute kidney injury develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alogliptin-metformin
Frequently asked questions
Can I take Alogliptin-metformin with Ibuprofen / famotidine?
MediHelp rates the interaction as minor. Alogliptin-metformin and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine is a cation handled by renal tubular secretion and may modestly raise metformin exposure. Ibuprofen can reduce renal function in susceptible patients, which could reduce metformin clearance. In patients with normal renal function the effect is usually small.
How serious is the interaction between Alogliptin-metformin and Ibuprofen / famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function in patients with kidney impairment, dehydration or advanced age, and hold metformin if acute kidney injury develops.
What other medicines interact with Alogliptin-metformin?
MediHelp also lists interactions of Alogliptin-metformin with, for example, Clozapine, Contrast media, Diatrizoate. The full list is on the Alogliptin-metformin page.
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