Drug interactions
Alogliptin-metformin + Insulin isophane human / insulin regular human
Severity: Moderate
Alogliptin-metformin and Insulin isophane human / insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using alogliptin and metformin with premixed human insulin produces additive glucose lowering. The risk of hypoglycemia rises, especially when the combination is newly started or the doses are changed.
What this interaction means in plain words
Alogliptin-metformin and Insulin isophane human / insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose-lowering effects through different mechanisms (exogenous insulin, DPP-4 inhibition, and reduced hepatic glucose output).
What to do
Monitor blood glucose when starting, stopping, or adjusting either agent and reduce the insulin dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms and treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Alogliptin-metformin and Insulin isophane human / insulin regular human, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Alogliptin-metformin
Frequently asked questions
Can I take Alogliptin-metformin with Insulin isophane human / insulin regular human?
MediHelp rates the interaction as moderate. Alogliptin-metformin and Insulin isophane human / insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using alogliptin and metformin with premixed human insulin produces additive glucose lowering. The risk of hypoglycemia rises, especially when the combination is newly started or the doses are changed.
How serious is the interaction between Alogliptin-metformin and Insulin isophane human / insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, stopping, or adjusting either agent and reduce the insulin dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms and treatment.
What other medicines interact with Alogliptin-metformin?
MediHelp also lists interactions of Alogliptin-metformin with, for example, Clozapine, Contrast media, Diatrizoate. The full list is on the Alogliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
