Drug interactions
Alogliptin-pioglitazone + Nortriptyline
Severity: Minor
Alogliptin-pioglitazone and Nortriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can alter glucose control, and hypoglycemia or hyperglycemia has occasionally been reported with antidiabetic agents. The effect on pioglitazone is unpredictable and usually small.
What this interaction means in plain words
Alogliptin-pioglitazone and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Alogliptin-pioglitazone belongs to Endocrine; Nortriptyline belongs to Central Nervous System.
Why it happens
Possible pharmacodynamic effect on glucose homeostasis and appetite; the mechanism is not well established.
What to do
Monitor blood glucose when nortriptyline is started, adjusted or stopped, and adjust antidiabetic therapy only if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Alogliptin-pioglitazone
Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Frequently asked questions
Can I take Alogliptin-pioglitazone with Nortriptyline?
MediHelp rates the interaction as minor. Alogliptin-pioglitazone and Nortriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants can alter glucose control, and hypoglycemia or hyperglycemia has occasionally been reported with antidiabetic agents. The effect on pioglitazone is unpredictable and usually small.
How serious is the interaction between Alogliptin-pioglitazone and Nortriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when nortriptyline is started, adjusted or stopped, and adjust antidiabetic therapy only if control changes.
What other medicines interact with Alogliptin-pioglitazone?
MediHelp also lists interactions of Alogliptin-pioglitazone with, for example, Gemfibrozil, Insulin aspart, Insulin degludec. The full list is on the Alogliptin-pioglitazone page.
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