Drug interactions
Alpelisib + Glibenclamide
Severity: Moderate
Alpelisib and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alpelisib may induce CYP2C9 and lower glyburide exposure, which could reduce glycemic control. Alpelisib itself commonly causes hyperglycemia, so loss of control may be compounded.
What this interaction means in plain words
Alpelisib and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Alpelisib belongs to Oncology; Glibenclamide belongs to Endocrine.
Why it happens
Alpelisib induction of CYP2C9 may increase glyburide metabolism.
What to do
Monitor blood glucose frequently during alpelisib therapy and adjust the glyburide dose or antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Alpelisib
- Alpelisib + Carbamazepine Major
- Alpelisib + Phenytoin Major
- Alpelisib + Secobarbital Major
- Alpelisib + Apalutamide Moderate
- Alpelisib + Bosentan Moderate
- Alpelisib + Chlorpropamide Moderate
Frequently asked questions
Can I take Alpelisib with Glibenclamide?
MediHelp rates the interaction as moderate. Alpelisib and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alpelisib may induce CYP2C9 and lower glyburide exposure, which could reduce glycemic control. Alpelisib itself commonly causes hyperglycemia, so loss of control may be compounded.
How serious is the interaction between Alpelisib and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during alpelisib therapy and adjust the glyburide dose or antidiabetic regimen as needed.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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