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Drug interactions

Alteplase + Dabigatran etexilate

Severity: Major

Alteplase and Dabigatran etexilate: major interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Alteplase dissolves clots while dabigatran inhibits thrombin, so together they greatly increase the risk of serious bleeding including intracranial hemorrhage.

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