Drug interactions
Aluminum hydroxide + Rilpivirine
Severity: Major
Aluminum hydroxide and Rilpivirine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids raise gastric pH, which decreases rilpivirine absorption, as rilpivirine needs acid for dissolution. Lower levels risk virologic failure and resistance.
What this interaction means in plain words
Aluminum hydroxide and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aluminum hydroxide belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.
Why it happens
Elevated gastric pH reduces rilpivirine solubility and oral absorption.
What to do
Give antacids at least 2 hours before or 4 hours after rilpivirine. For the dolutegravir/rilpivirine combination tablet, use at least 4 hours before or 6 hours after.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Aluminum hydroxide
Frequently asked questions
Can I take Aluminum hydroxide with Rilpivirine?
MediHelp rates the interaction as major. Aluminum hydroxide and Rilpivirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antacids raise gastric pH, which decreases rilpivirine absorption, as rilpivirine needs acid for dissolution. Lower levels risk virologic failure and resistance.
How serious is the interaction between Aluminum hydroxide and Rilpivirine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give antacids at least 2 hours before or 4 hours after rilpivirine. For the dolutegravir/rilpivirine combination tablet, use at least 4 hours before or 6 hours after.
What other medicines interact with Aluminum hydroxide?
MediHelp also lists interactions of Aluminum hydroxide with, for example, Ciprofloxacin, Deferasirox, Dolutegravir. The full list is on the Aluminum hydroxide page.
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