Drug interactions
aluminum hydroxide + ciprofloxacin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Aluminum binds ciprofloxacin in the gut and markedly reduces its absorption. This can lead to subtherapeutic antibiotic levels and treatment failure.
Mechanism of action
Chelation of ciprofloxacin by aluminum cations, forming poorly absorbed complexes.
Clinical management
Give ciprofloxacin at least 2 hours before or 6 hours after aluminum-containing antacids.
Drug reference
Frequently asked questions
Can I take aluminum hydroxide with ciprofloxacin?
The interaction is rated: Major. Aluminum binds ciprofloxacin in the gut and markedly reduces its absorption. This can lead to subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between aluminum hydroxide and ciprofloxacin?
The interaction is rated: Major. Evidence level: High.
How is the interaction between aluminum hydroxide and ciprofloxacin managed?
Give ciprofloxacin at least 2 hours before or 6 hours after aluminum-containing antacids.
Why do aluminum hydroxide and ciprofloxacin interact?
Chelation of ciprofloxacin by aluminum cations, forming poorly absorbed complexes.
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