Drug interactions
Aluminum hydroxide / magnesium carbonate + Sofosbuvir-velpatasvir
Severity: Moderate
Aluminum hydroxide / magnesium carbonate and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir solubility falls as gastric pH rises, so antacids can reduce its absorption and potentially lower antiviral efficacy. This matters because reduced exposure may risk virologic failure.
What this interaction means in plain words
Aluminum hydroxide / magnesium carbonate and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antacid-induced increase in gastric pH reduces velpatasvir dissolution and absorption.
What to do
Separate administration of sofosbuvir/velpatasvir and the antacid by at least 4 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir
- Rifampin + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Sofosbuvir-velpatasvir + St john's wort Contraindicated
- Amiodarone + Sofosbuvir-velpatasvir Major
- Apalutamide + Sofosbuvir-velpatasvir Major
- Carbamazepine + Sofosbuvir-velpatasvir Major
Frequently asked questions
Can I take Aluminum hydroxide / magnesium carbonate with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Aluminum hydroxide / magnesium carbonate and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir solubility falls as gastric pH rises, so antacids can reduce its absorption and potentially lower antiviral efficacy. This matters because reduced exposure may risk virologic failure.
How serious is the interaction between Aluminum hydroxide / magnesium carbonate and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration of sofosbuvir/velpatasvir and the antacid by at least 4 hours.
What other medicines interact with Sofosbuvir-velpatasvir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir with, for example, Rifampin, Rifapentine, St john's wort. The full list is on the Sofosbuvir-velpatasvir page.
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