Drug interactions
Aluminum hydroxide / magnesium trisilicate + Nilotinib
Severity: Moderate
Aluminum hydroxide / magnesium trisilicate and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids raise gastric pH, and nilotinib solubility and absorption fall at higher pH. Exposure may drop and reduce efficacy.
What this interaction means in plain words
Aluminum hydroxide / magnesium trisilicate and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Elevated gastric pH reduces dissolution and absorption of nilotinib.
What to do
Give the antacid at least 2 hours before or 2 hours after nilotinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Aluminum hydroxide / magnesium trisilicate with Nilotinib?
MediHelp rates the interaction as moderate. Aluminum hydroxide / magnesium trisilicate and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids raise gastric pH, and nilotinib solubility and absorption fall at higher pH. Exposure may drop and reduce efficacy.
How serious is the interaction between Aluminum hydroxide / magnesium trisilicate and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the antacid at least 2 hours before or 2 hours after nilotinib.
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