Drug interactions
Aluminum hydroxide / magnesium trisilicate + Sofosbuvir-velpatasvir
Severity: Moderate
Aluminum hydroxide / magnesium trisilicate and Sofosbuvir-velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir solubility falls as gastric pH rises, so antacids can reduce its absorption and potentially lower antiviral efficacy. This matters because reduced exposure may risk virologic failure.
What this interaction means in plain words
Aluminum hydroxide / magnesium trisilicate and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antacid-induced increase in gastric pH reduces velpatasvir dissolution and absorption.
What to do
Separate administration of sofosbuvir/velpatasvir and the antacid by at least 4 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Aluminum hydroxide / magnesium trisilicate with Sofosbuvir-velpatasvir?
MediHelp rates the interaction as moderate. Aluminum hydroxide / magnesium trisilicate and Sofosbuvir-velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir solubility falls as gastric pH rises, so antacids can reduce its absorption and potentially lower antiviral efficacy. This matters because reduced exposure may risk virologic failure.
How serious is the interaction between Aluminum hydroxide / magnesium trisilicate and Sofosbuvir-velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration of sofosbuvir/velpatasvir and the antacid by at least 4 hours.
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