Drug interactions
Alvimopan + Itraconazole
Severity: Minor
Alvimopan and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole inhibits P-glycoprotein and may increase alvimopan levels. Alvimopan is used for short periods after bowel resection and the observed effect of P-gp inhibitors on its exposure is not clinically significant.
What this interaction means in plain words
Alvimopan and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition by itraconazole may modestly reduce alvimopan efflux.
What to do
No dose adjustment is usually needed. Be aware of increased gastrointestinal or other adverse effects during short-term alvimopan use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
Frequently asked questions
Can I take Alvimopan with Itraconazole?
MediHelp rates the interaction as minor. Alvimopan and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole inhibits P-glycoprotein and may increase alvimopan levels. Alvimopan is used for short periods after bowel resection and the observed effect of P-gp inhibitors on its exposure is not clinically significant.
How serious is the interaction between Alvimopan and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Be aware of increased gastrointestinal or other adverse effects during short-term alvimopan use.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam. The full list is on the Itraconazole page.
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