Drug interactions
Alvimopan + Ketoconazole
Severity: Minor
Alvimopan and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole may modestly raise alvimopan levels. The effect is not considered clinically meaningful and alvimopan is used only short term in hospital.
What this interaction means in plain words
Alvimopan and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition by ketoconazole slightly increases alvimopan exposure.
What to do
No dose adjustment is usually needed. Be aware of increased gastrointestinal effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
Frequently asked questions
Can I take Alvimopan with Ketoconazole?
MediHelp rates the interaction as minor. Alvimopan and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole may modestly raise alvimopan levels. The effect is not considered clinically meaningful and alvimopan is used only short term in hospital.
How serious is the interaction between Alvimopan and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Be aware of increased gastrointestinal effects.
What other medicines interact with Ketoconazole?
MediHelp also lists interactions of Ketoconazole with, for example, Alfuzosin, Alprazolam. The full list is on the Ketoconazole page.
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