Drug interactions
Alvimopan + Lapatinib
Severity: Minor
Alvimopan and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alvimopan is a P-glycoprotein substrate, and lapatinib inhibits P-gp. Systemic exposure to alvimopan may increase slightly, but it is used only briefly in hospitalized patients.
What this interaction means in plain words
Alvimopan and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Lapatinib inhibits P-gp-mediated efflux of alvimopan.
What to do
No routine dose change is needed for the short alvimopan course. Monitor for adverse effects such as gastrointestinal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lapatinib
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Alvimopan with Lapatinib?
MediHelp rates the interaction as minor. Alvimopan and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Alvimopan is a P-glycoprotein substrate, and lapatinib inhibits P-gp. Systemic exposure to alvimopan may increase slightly, but it is used only briefly in hospitalized patients.
How serious is the interaction between Alvimopan and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for the short alvimopan course. Monitor for adverse effects such as gastrointestinal symptoms.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Adagrasib. The full list is on the Lapatinib page.
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