Drug interactions
Alvimopan + Nilotinib
Severity: Minor
Alvimopan and Nilotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib inhibits P-glycoprotein and may increase alvimopan exposure. The clinical significance is unclear because alvimopan is used only briefly in hospital.
What this interaction means in plain words
Alvimopan and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nilotinib inhibits P-gp efflux of alvimopan.
What to do
No routine adjustment is needed. Monitor for gastrointestinal adverse effects during short-term alvimopan use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Alvimopan with Nilotinib?
MediHelp rates the interaction as minor. Alvimopan and Nilotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nilotinib inhibits P-glycoprotein and may increase alvimopan exposure. The clinical significance is unclear because alvimopan is used only briefly in hospital.
How serious is the interaction between Alvimopan and Nilotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for gastrointestinal adverse effects during short-term alvimopan use.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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