Drug interactions
Alvimopan + Quinidine
Severity: Minor
Alvimopan and Quinidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alvimopan is a P-gp substrate and quinidine inhibits P-gp, which may raise alvimopan levels. The clinical effect is probably small with short-term use.
What this interaction means in plain words
Alvimopan and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of P-gp efflux by quinidine increases alvimopan exposure.
What to do
No dose adjustment is generally required for the short postoperative course. Monitor for gastrointestinal adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
Frequently asked questions
Can I take Alvimopan with Quinidine?
MediHelp rates the interaction as minor. Alvimopan and Quinidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Alvimopan is a P-gp substrate and quinidine inhibits P-gp, which may raise alvimopan levels. The clinical effect is probably small with short-term use.
How serious is the interaction between Alvimopan and Quinidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required for the short postoperative course. Monitor for gastrointestinal adverse effects.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib. The full list is on the Quinidine page.
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