Drug reference
quinidine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Anti Parasitic (Anti Malaria)
Mechanism of action
Class IA (membrane stabilizing) antiarrhythmic agent; inhibits recovery after repolarization resulting in decreasing myocardial excitability & conduction velocity Direct membrane depressant that decreases conduction velocity, prolongs refractoriness, decreases automaticity and reduces repolarization abnormalities
Common side effects
- Bitter taste
- Lightheadedness
- Anorexia
- QTc prolongation
- Stomach cramping
- Diarrhea
Contraindications
- Hypersensitivity to quinidine or cinchona alkaloids Myasthenia gravis, thrombocytopenia or developed thrombocytopenic purpura during prior therapy with quinidine or quinine Heart block >1st degree Idioventricular conduction delays, including patients in complete atrioventricular block (exc…
Known interactions (27)
- chloroquine + quinidine Contraindicated
- dronedarone + quinidine Contraindicated
- fingolimod + quinidine Contraindicated
- fluconazole + quinidine Contraindicated
- itraconazole + quinidine Contraindicated
- adrenaline-articaine + quinidine Major
- amitriptyline + quinidine Major
- aripiprazole + quinidine Major
- chlorpromazine + quinidine Major
- clarithromycin + quinidine Major
- clomipramine + quinidine Major
- clozapine + quinidine Major
- colchicine + quinidine Major
- desipramine + quinidine Major
- donepezil + quinidine Major
- dosulepin + quinidine Major
- epinephrine + quinidine Major
- erythromycin + quinidine Major
- fluphenazine + quinidine Major
- gemifloxacin + quinidine Major
- goserelin + quinidine Major
- haloperidol + quinidine Major
- imipramine + quinidine Major
- indapamide + quinidine Major
- quinidine + ritonavir Major
- diphenhydramine + quinidine Moderate
- flibanserin + quinidine Moderate
Related conditions
Frequently asked questions
What drug class is quinidine?
quinidine belongs to: Anti Parasitic.
How does quinidine work?
Class IA (membrane stabilizing) antiarrhythmic agent; inhibits recovery after repolarization resulting in decreasing myocardial excitability & conduction velocity Direct membrane depressant that decreases conduction velocity, prolongs refractoriness, decreases automaticity and reduces repolarization abnormalities
What are the common side effects of quinidine?
Bitter taste, Lightheadedness, Anorexia, QTc prolongation, Stomach cramping, Diarrhea
Which drugs interact with quinidine?
chloroquine, dronedarone, fingolimod, fluconazole, itraconazole, adrenaline-articaine, amitriptyline, aripiprazole, chlorpromazine, clarithromycin, clomipramine, clozapine, colchicine, desipramine, donepezil
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