Drug interactions
Alvimopan + Sirolimus
Severity: Minor
Alvimopan and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may inhibit P-glycoprotein and increase alvimopan levels. Alvimopan is given only short-term in hospital and the clinical effect is probably small.
What this interaction means in plain words
Alvimopan and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-gp inhibition by sirolimus reducing alvimopan efflux.
What to do
No routine adjustment is needed; monitor for gastrointestinal adverse effects during the short alvimopan course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
Frequently asked questions
Can I take Alvimopan with Sirolimus?
MediHelp rates the interaction as minor. Alvimopan and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sirolimus may inhibit P-glycoprotein and increase alvimopan levels. Alvimopan is given only short-term in hospital and the clinical effect is probably small.
How serious is the interaction between Alvimopan and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for gastrointestinal adverse effects during the short alvimopan course.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live. The full list is on the Sirolimus page.
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