Drug interactions
Alvimopan + Tacrolimus
Severity: Minor
Alvimopan and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may raise alvimopan concentrations through P-glycoprotein effects, but alvimopan is used only short term after bowel surgery and the clinical impact is likely small.
What this interaction means in plain words
Alvimopan and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition by tacrolimus reduces alvimopan efflux.
What to do
No routine adjustment is needed; observe for gastrointestinal adverse effects during the short alvimopan course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Alvimopan and Tacrolimus interact, what to do about it, and the sources.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Alvimopan with Tacrolimus?
MediHelp rates the interaction as minor. Alvimopan and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrolimus may raise alvimopan concentrations through P-glycoprotein effects, but alvimopan is used only short term after bowel surgery and the clinical impact is likely small.
How serious is the interaction between Alvimopan and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; observe for gastrointestinal adverse effects during the short alvimopan course.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
