Drug interactions
Alvimopan + Tolvaptan
Severity: Minor
Alvimopan and Tolvaptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolvaptan inhibits P-glycoprotein and may modestly increase alvimopan exposure. The clinical impact is uncertain, and alvimopan is used only short term in hospital.
What this interaction means in plain words
Alvimopan and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition by tolvaptan may reduce alvimopan efflux.
What to do
No routine adjustment is needed; watch for gastrointestinal adverse effects of alvimopan during short-term use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Frequently asked questions
Can I take Alvimopan with Tolvaptan?
MediHelp rates the interaction as minor. Alvimopan and Tolvaptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tolvaptan inhibits P-glycoprotein and may modestly increase alvimopan exposure. The clinical impact is uncertain, and alvimopan is used only short term in hospital.
How serious is the interaction between Alvimopan and Tolvaptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for gastrointestinal adverse effects of alvimopan during short-term use.
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