Drug reference
tolvaptan
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Endocrine (Pituitary Hormones)
Mechanism of action
Selective vasopressin V2-receptor antagonist that causes an increase in urine water excretion that results in an increase in free water clearance (aquaresis), a decrease in urine osmolality, and a resulting increase in serum sodium concentration
Common side effects
- Dry mouth
- Nausea
- Thirst
- Pollakiuria
- Urinary frequency/output increased
Known interactions (9)
- itraconazole + tolvaptan Contraindicated
- aprepitant + tolvaptan Major
- dronedarone + tolvaptan Major
- fluconazole + tolvaptan Major
- griseofulvin + tolvaptan Major
- chloramphenicol + tolvaptan Moderate
- dasatinib + tolvaptan Moderate
- efavirenz + tolvaptan Moderate
- fluvoxamine + tolvaptan Moderate
Related conditions
Frequently asked questions
What drug class is tolvaptan?
tolvaptan belongs to: Endocrine.
How does tolvaptan work?
Selective vasopressin V2-receptor antagonist that causes an increase in urine water excretion that results in an increase in free water clearance (aquaresis), a decrease in urine osmolality, and a resulting increase in serum sodium concentration
What are the common side effects of tolvaptan?
Dry mouth, Nausea, Thirst, Pollakiuria, Urinary frequency/output increased
Which drugs interact with tolvaptan?
itraconazole, aprepitant, dronedarone, fluconazole, griseofulvin, chloramphenicol, dasatinib, efavirenz, fluvoxamine
Full monographs, dosing and an interaction checker in the MediHelp app
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