Drug interactions
Amantadine + Atropine iv /
Severity: Moderate
Amantadine and Atropine iv /: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic activity, and systemic atropine can add to amantadine's effects on the central nervous system and peripheral antimuscarinic effects. This may cause confusion, hallucinations, delirium, tachycardia, urinary retention and dry mouth, particularly in older patients.
What this interaction means in plain words
Amantadine and Atropine iv / can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central and peripheral anticholinergic effects.
What to do
Monitor for confusion, hallucinations, tachycardia and urinary retention, and use the lowest effective atropine dose in older or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Atropine iv /?
MediHelp rates the interaction as moderate. Amantadine and Atropine iv / can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic activity, and systemic atropine can add to amantadine's effects on the central nervous system and peripheral antimuscarinic effects. This may cause confusion, hallucinations, delirium, tachycardia, urinary retention and dry mouth, particularly in older patients.
How serious is the interaction between Amantadine and Atropine iv /?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for confusion, hallucinations, tachycardia and urinary retention, and use the lowest effective atropine dose in older or renally impaired patients.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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