Drug interactions
Amantadine + Belladonna alkaloids
Severity: Moderate
Amantadine and Belladonna alkaloids: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Belladonna alkaloids are antimuscarinic and can add to amantadine's anticholinergic effects. This increases the risk of confusion, hallucinations, dry mouth, constipation, urinary retention and tachycardia, especially in older adults.
What this interaction means in plain words
Amantadine and Belladonna alkaloids can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic pharmacodynamic effects.
What to do
Monitor for anticholinergic toxicity and reduce the antimuscarinic dose or consider alternatives if confusion or retention develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Belladonna alkaloids?
MediHelp rates the interaction as moderate. Amantadine and Belladonna alkaloids can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Belladonna alkaloids are antimuscarinic and can add to amantadine's anticholinergic effects. This increases the risk of confusion, hallucinations, dry mouth, constipation, urinary retention and tachycardia, especially in older adults.
How serious is the interaction between Amantadine and Belladonna alkaloids?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and reduce the antimuscarinic dose or consider alternatives if confusion or retention develops.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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