Drug interactions
Amantadine + Belladonna and opium
Severity: Moderate
Amantadine and Belladonna and opium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The belladonna component adds antimuscarinic effects to those of amantadine, while the opium component adds constipation and sedation. Together they may cause confusion, urinary retention, constipation and excess sedation, especially in older patients.
What this interaction means in plain words
Amantadine and Belladonna and opium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive anticholinergic effects, with additional opioid-related CNS depression and reduced gut motility.
What to do
Monitor for confusion, sedation, urinary retention and constipation, and use the lowest effective dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Amantadine and Belladonna and opium interact, what to do about it, and the sources.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Belladonna and opium?
MediHelp rates the interaction as moderate. Amantadine and Belladonna and opium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The belladonna component adds antimuscarinic effects to those of amantadine, while the opium component adds constipation and sedation. Together they may cause confusion, urinary retention, constipation and excess sedation, especially in older patients.
How serious is the interaction between Amantadine and Belladonna and opium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for confusion, sedation, urinary retention and constipation, and use the lowest effective dose for the shortest time.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
