Drug interactions
Amantadine + Caffeine
Severity: Minor
Amantadine and Caffeine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine and amantadine can both cause CNS stimulation, so large caffeine intake may add to nervousness, insomnia or tremor in patients on amantadine. The effect is generally mild.
What this interaction means in plain words
Amantadine and Caffeine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amantadine belongs to Anti Virals; Caffeine belongs to Miscellaneous.
Why it happens
Additive CNS stimulation (caffeine adenosine antagonism plus amantadine dopaminergic activity).
What to do
Advise limiting caffeine intake if insomnia, restlessness or tremor develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Other interactions of Caffeine
- Adenosine + Caffeine Moderate
Frequently asked questions
Can I take Amantadine with Caffeine?
MediHelp rates the interaction as minor. Amantadine and Caffeine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caffeine and amantadine can both cause CNS stimulation, so large caffeine intake may add to nervousness, insomnia or tremor in patients on amantadine. The effect is generally mild.
How serious is the interaction between Amantadine and Caffeine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise limiting caffeine intake if insomnia, restlessness or tremor develops.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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