Drug interactions
Amantadine + Calcium acetate
Severity: Minor
Amantadine and Calcium acetate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amantadine is excreted unchanged by the kidney and its clearance falls as urine becomes more alkaline. Calcium acetate may have a modest alkalinizing effect, which could raise amantadine levels and cause confusion, hallucinations or dizziness.
What this interaction means in plain words
Amantadine and Calcium acetate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amantadine belongs to Anti Virals; Calcium acetate belongs to Genitourinary.
Why it happens
Urinary alkalinization reduces renal elimination of amantadine.
What to do
No dose change is usually needed. Monitor for amantadine adverse effects, especially in elderly patients or those with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Other interactions of Calcium acetate
- Alendronate + Calcium acetate Moderate
Frequently asked questions
Can I take Amantadine with Calcium acetate?
MediHelp rates the interaction as minor. Amantadine and Calcium acetate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Amantadine is excreted unchanged by the kidney and its clearance falls as urine becomes more alkaline. Calcium acetate may have a modest alkalinizing effect, which could raise amantadine levels and cause confusion, hallucinations or dizziness.
How serious is the interaction between Amantadine and Calcium acetate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for amantadine adverse effects, especially in elderly patients or those with renal impairment.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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