Drug interactions
Amantadine + Calcium carbonate
Severity: Minor
Amantadine and Calcium carbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium carbonate can raise urinary pH. Amantadine is eliminated mainly unchanged by the kidney, and its excretion falls in alkaline urine, so levels may rise. This could increase CNS or anticholinergic adverse effects, especially in older patients or those with renal impairment.
What this interaction means in plain words
Amantadine and Calcium carbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amantadine belongs to Anti Virals; Calcium carbonate belongs to Gastrointestinal Tract.
Why it happens
Urinary alkalinization reduces renal tubular excretion of amantadine, leading to accumulation.
What to do
Monitor for amantadine adverse effects such as confusion, hallucinations, dizziness and insomnia when regular high-dose calcium carbonate is used. Reduce the amantadine dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium carbonate
- Acalabrutinib + Calcium carbonate Moderate
- Alendronate + Calcium carbonate Moderate
Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Calcium carbonate?
MediHelp rates the interaction as minor. Amantadine and Calcium carbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium carbonate can raise urinary pH. Amantadine is eliminated mainly unchanged by the kidney, and its excretion falls in alkaline urine, so levels may rise. This could increase CNS or anticholinergic adverse effects, especially in older patients or those with renal impairment.
How serious is the interaction between Amantadine and Calcium carbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for amantadine adverse effects such as confusion, hallucinations, dizziness and insomnia when regular high-dose calcium carbonate is used. Reduce the amantadine dose if toxicity appears.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate. The full list is on the Calcium carbonate page.
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