Drug interactions
Amantadine + Calcium citrate
Severity: Minor
Amantadine and Calcium citrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citrate is metabolized to bicarbonate and can alkalinize the urine. Alkaline urine reduces amantadine excretion, so levels may rise modestly and cause more CNS adverse effects.
What this interaction means in plain words
Amantadine and Calcium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Urinary alkalinization decreases renal clearance of amantadine.
What to do
Monitor for confusion, hallucinations and dizziness, particularly in older or renally impaired patients. Reduce the amantadine dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Calcium citrate?
MediHelp rates the interaction as minor. Amantadine and Calcium citrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Citrate is metabolized to bicarbonate and can alkalinize the urine. Alkaline urine reduces amantadine excretion, so levels may rise modestly and cause more CNS adverse effects.
How serious is the interaction between Amantadine and Calcium citrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for confusion, hallucinations and dizziness, particularly in older or renally impaired patients. Reduce the amantadine dose if toxicity appears.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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