Drug interactions
Amantadine + Calcium
Severity: Minor
Amantadine and Calcium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium salts with alkalinizing effects may raise urinary pH. Amantadine is eliminated mainly unchanged by the kidney, and alkaline urine can reduce its excretion, so levels may rise. This could increase dose-related adverse effects such as confusion, hallucinations or dizziness.
What this interaction means in plain words
Amantadine and Calcium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amantadine belongs to Anti Virals; Calcium belongs to Gastrointestinal Tract.
Why it happens
Urinary alkalinization reduces renal tubular elimination of amantadine, a weak base, leading to accumulation.
What to do
No routine change is needed for typical doses. Watch for CNS adverse effects of amantadine in patients with renal impairment or on high-dose alkalinizing therapy, and reduce the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Calcium?
MediHelp rates the interaction as minor. Amantadine and Calcium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium salts with alkalinizing effects may raise urinary pH. Amantadine is eliminated mainly unchanged by the kidney, and alkaline urine can reduce its excretion, so levels may rise. This could increase dose-related adverse effects such as confusion, hallucinations or dizziness.
How serious is the interaction between Amantadine and Calcium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed for typical doses. Watch for CNS adverse effects of amantadine in patients with renal impairment or on high-dose alkalinizing therapy, and reduce the dose if they occur.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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