Drug interactions
Amantadine + Erdafitinib
Severity: Moderate
Amantadine and Erdafitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amantadine is cleared by renal tubular secretion through OCT2. Erdafitinib inhibits OCT2 and may raise amantadine concentrations, increasing the risk of confusion, hallucinations and other CNS effects.
What this interaction means in plain words
Amantadine and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amantadine belongs to Anti Virals; Erdafitinib belongs to Oncology.
Why it happens
Inhibition of OCT2-mediated renal tubular secretion of amantadine.
What to do
Monitor for amantadine toxicity and consider reducing its dose based on tolerability. Use an alternative that is not an OCT2 substrate if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amantadine
- Amantadine + Ethanol Major
- Amantadine + Memantine-donepezil Major
- Amantadine + Metoclopramide Major
- Amantadine + Metoclopramide intranasal Major
- Amantadine + Amifampridine Moderate
- Amantadine + Amisulpride Moderate
Frequently asked questions
Can I take Amantadine with Erdafitinib?
MediHelp rates the interaction as moderate. Amantadine and Erdafitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amantadine is cleared by renal tubular secretion through OCT2. Erdafitinib inhibits OCT2 and may raise amantadine concentrations, increasing the risk of confusion, hallucinations and other CNS effects.
How serious is the interaction between Amantadine and Erdafitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for amantadine toxicity and consider reducing its dose based on tolerability. Use an alternative that is not an OCT2 substrate if toxicity develops.
What other medicines interact with Amantadine?
MediHelp also lists interactions of Amantadine with, for example, Ethanol, Memantine-donepezil, Metoclopramide. The full list is on the Amantadine page.
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